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盐酸金霉素是一种有效的广谱抗生素,由于疗效好、毒性低,曾为临床广泛应用。近年来据临床评议,不少病员在口服金霉素后对胃肠反应较大,以致有日趋不受病员欢迎之势。如何对本品进行改进,以发挥其应有的作用,就成了我们亟须解决的问题。 根据有关学者的研究及文献报导,发现四环类抗生素在生产和贮存过程中有发生可逆的同分异构作用,形成一种与抗生素构造近似而抗菌作用很小、毒性较大的物质,即
Chlortetracycline hydrochloride is an effective broad-spectrum antibiotic, which has been widely used clinically because of its good curative effect and low toxicity. In recent years, according to clinical evaluation, many patients after oral administration of chlortetracycline greater gastrointestinal reaction, so that patients increasingly welcome the trend. How to improve this product, to play its due role, it has become an issue that we must solve. According to the relevant scholars’ research and literature reports, it was found that tetracycline antibiotics have reversible isomerization effect during production and storage, forming a substance with similar antibiotic structure and small antibacterial activity and high toxicity, namely,