氧瓶燃烧—双波长扫描法测定有机药物中微量砷

• 作 者: 肖义菊 尹光华
• 机 构: 华西医科大学,华西医科大学 成都,成都
• 出 处: 华西药学杂志
• 发表日期: 1987年01期
• 关键词: 波长扫描法 氧瓶燃烧法 碱熔法 氢氧化钙 预处理过程 砷盐 称样量 砷斑 碳酸钠溶液 以同

测定有些药物中的微量砷,需经破坏有机物的预处理过程,使之转化为可溶性砷盐再进行测定。目前常见的破坏方法有氢氧化钙碱熔法、硫酸—硝酸法、硫酸—过氧化氢法、氧瓶燃烧法。以上各法费时费事或称样量较少。本文采取电热点火、流通供氧的氧瓶燃烧法,将常量样品在几十秒钟内完全燃烧后,用碳酸钠溶液吸收,按中国药典方法制成砷斑,采用双波长扫描法测得砷的含量,与样品用碱熔法处理后以同法测得砷的结果,经t检验表明,两者平均值之间无显著性差异。

Determination of trace amounts of arsenic drugs, the need to destroy the pretreatment of organic matter, making it into soluble arsenic salt and then measured. Commonly used methods of destruction are calcium hydroxide alkali melting method, sulfuric acid - nitric acid method, sulfuric acid - hydrogen peroxide method, oxygen bottle combustion method. The above method is time-consuming or weighed less sample. In this paper, electric ignition, circulating oxygen supply oxygen bottle combustion method, the constant sample in a few dozen seconds after the complete combustion, sodium carbonate solution absorption, according to the Chinese Pharmacopoeia method of making arsenic stain, using dual wavelength scanning method for the determination of arsenic The results of t test showed that there was no significant difference between the two methods.