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目的研究血清和腹水转甲状腺素(TTR)蛋白含量和化学修饰类型,在肺癌诊断中的作用。方法日本东芝TBA120全自动生化分析仪测定血清和胸水总蛋白(TP)、白蛋白(Alb)、甘油三酯(TG)、胆固醇(TC)、乳酸脱氢酶(LDH)及葡萄糖(GLU)的含量。免疫比浊法测定TTR、Apo A和Apo B三种蛋白含量。基〗结果胸水中有6种成分含量比血清明显减低,减低程度明显的顺序依次是:TG、TC、Apo A、Apo B和TTR,而增高的仅LDH一项指标。在蛋白指标中TTR减低最明显。肺癌患者胸水TTR发生3种类型化学修饰,其中GLUT-TTR修饰型明显增高。结论肺癌患者胸水TTR含量明显低于血清,并且glut-TTR修饰比例明显增高,可能作为肺癌诊断的辅助参考指标。
Objective To study the role of thyroid hormone (TTR) in serum and ascites in the diagnosis of lung cancer. Methods TBA120 automatic biochemical analyzer was used to measure the levels of total protein (TP), albumin (Alb), triglyceride (TG), cholesterol (TC), lactate dehydrogenase (LDH) and glucose (GLU) content. Immunoturbidimetric assay for TTR, Apo A and Apo B three protein content. The results of pleural effusion in 6 kinds of ingredients were significantly lower than the serum levels were significantly reduced in order: TG, TC, Apo A, Apo B and TTR, elevated LDH only an indicator. The most obvious reduction of TTR in protein index. Three types of chemical modifications of pleural fluid TTR in lung cancer patients, including GLUT-TTR modified significantly increased. Conclusions The content of TTR in pleural fluid of patients with lung cancer is significantly lower than that in serum, and the proportion of glut-TTR modification is significantly higher, which may be used as a supplementary reference index in the diagnosis of lung cancer.