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目的探讨Ⅳ型胶原（ＣⅣ）、透明质酸（ＨＡ）和肿瘤坏死因子α（ＴＮＦα）在肝病中的临床意义．方法对９４例不同类型肝病应用一步夹心固相酶免疫法检测血清ＣⅣ活性，并应用放射免疫法检测血清ＨＡ和ＴＮＦα活性．结果不同类型的肝炎、肝硬变、原发性肝癌（ＨＣＣ）患者的血清ＣⅣ，ＨＡ和ＴＮＦα含量较对照组明显升高（Ｐ＜００５），ＣⅣ以重症肝炎的含量（μｇ／Ｌ）最高（７７３±４７５），ＨＡ（μｇ／Ｌ）以硬化型ＨＣＣ的含量最高（１３１１±９８０），ＴＮＦα（ｐｍｏｌ／Ｌ）以重症肝炎的含量最高（２２５±５０）．血清ＣⅣ，ＨＡ含量与ＴＮＦα含量呈正相关．结论血清ＣⅣ和ＨＡ升高反映早期肝纤维化程度，ＴＮＦα参与肝纤维化的形成．
Objective To investigate the clinical significance of type Ⅳ collagen (C Ⅳ), hyaluronic acid (HA) and tumor necrosis factor α (TNFα) in hepatopathy. Methods 94 cases of different types of liver disease by one-step sandwich enzyme immunoassay serum C Ⅳ activity, and the application of radioimmunoassay serum HA and TNFα activity. Results The levels of CⅣ, HA and TNFα in patients with different types of hepatitis, cirrhosis and primary liver cancer (HCC) were significantly higher than those in the control group (P <005) ) Was the highest (773 ± 475), HA (μg / L) was the highest in sclerotic HCC (1311 ± 980), and TNFα (pmol / L) was the highest in severe hepatitis (225 ± 50). Serum CⅣ, HA content and TNFα content was positively correlated. Conclusions The elevated serum CⅣ and HA reflect the degree of early liver fibrosis, and TNFα is involved in the formation of hepatic fibrosis.