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目的 :探讨骨质修复作为多发性骨髓瘤 (MM )疗效主要标准的价值。方法 :统计经M2 方案治疗 2个疗程以上的MM 2 2例。治疗前后均有骨骼X线片对照 ,评价治疗后骨骼病变转归、部分实验室资料及生活自理程度的变化。结果 :治疗后临床症状、体征、生活自理程度、主要实验室指标均明显改善 ,但骨骼病变好转率仅 10 % ,生活自理程度的改善与骨骼病变改善无相关性 (rs=0 0 0 ,P =1 0 )。结论 :结合我们及其他作者的研究。MM治疗后溶骨损害修复率低 ,与病情恢复不平行 ,作为疗效判别主要指标的价值值得进一步商榷
Objective: To explore the value of bone repair as the main criterion for the efficacy of multiple myeloma (MM). Methods : A total of 2 cases of MM with more than 2 courses of treatment were treated with M2 regimen. Before and after treatment, there were bone X-ray films to evaluate the changes of bone disease after treatment, some laboratory data and self-care degree of life. Results: Clinical symptoms, physical signs, self-care levels, and main laboratory indicators improved significantly after treatment, but the improvement rate of skeletal lesions was only 10%. There was no correlation between improvement of self-care levels and improvement of skeletal lesions (rs=0 0 0 ,P). =1 0 ). Conclusion : Combine our research with other authors. After MM treatment, the repair rate of osteolytic lesions is low, which is not parallel to the recovery of the disease. The value of the main indicators of efficacy evaluation is worth further discussion.