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背景:传统观点认为高压氧可以防治脑梗死,但在高压氧治疗中有诱发脑梗死的病例报告。目的:分析高压氧过程中诱发脑梗死的危险因素。设计:以患者为观察对象的病例分析。单位:广州军区广州总医院高压氧科。对象:观察对象为1996-12/1998-03广州军区广州总医院行高压氧治疗的的192例住院患者,男127例,女65例;年龄9～78岁。接受高压氧治疗中发生脑梗死的患者共6例,男女各3例;年龄51～76岁。方法:对192例行高压氧治疗患者及其中发生的6例脑梗死患者的背景因素进行分析。主要观察指标:患者的症状、体征以及头颅CT 或M RI变化。结果:按意向处理分析,192例患者进入结果分析。①高压氧治疗过程中脑梗死发生率为0.3%(6/192)。②发现高压氧诱发脑梗死以年龄≥60岁、高血压病、高脂血症、原有脑梗死(或脑出血)、高黏血症及糖尿病等基础疾病为危险因子,危险因子簇集4个以下者不发病,4个或4个以上者发病率大为增加。结论:危险因子的簇集性水平与高压氧诱发脑梗死发生概率有密切关系。
Background: The traditional view that hyperbaric oxygen can prevent cerebral infarction, but hyperbaric oxygen therapy has induced cerebral infarction in the case report. Objective: To analyze the risk factors of cerebral infarction induced by hyperbaric oxygen. Design: case analysis of patients as the object of observation. Unit: Guangzhou Military Region, Guangzhou General Hospital hyperbaric oxygen. PARTICIPANTS: The observed objects were 192 hospitalized patients with hyperbaric oxygen therapy in Guangzhou General Hospital of Guangzhou Military Command from December 1996 to March 1998, including 127 males and 65 females, aged 9-78 years. There were 6 patients with cerebral infarction receiving hyperbaric oxygen therapy, 3 males and 3 females, aged 51-76 years. Methods: 192 patients with hyperbaric oxygen therapy and 6 cases of cerebral infarction in patients with background factors were analyzed. MAIN OUTCOME MEASURES: Patient’s symptoms and signs as well as CT or M RI changes in the skull. Results: According to intention-to-treat analysis, 192 patients entered the result analysis. ① The incidence of cerebral infarction during hyperbaric oxygen therapy was 0.3% (6/192). ② found that hyperbaric oxygen-induced cerebral infarction to age ≥ 60 years old, hypertension, hyperlipidemia, the original cerebral infarction (or cerebral hemorrhage), hyperviscosity and diabetes and other underlying diseases as risk factors, clustering of risk factors 4 The following were not onset, 4 or more significantly increased the incidence of more than 4. Conclusion: The clustering level of risk factors is closely related to the incidence of cerebral infarction induced by hyperbaric oxygen.