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目的 研究胃癌组织中ＨＳＰ６０和ＨＳＰ７０的表达及其意义。方法将胃癌组织石蜡包埋切片，以ＡＢＣ免疫组织化学法染色进行观察。结果５０例胃癌ＨＳＰ６０和ＨＳＰ７０阳性率分别为５６％和６４％，高分化和未发生淋巴结转移的胃癌ＨＳＰ６０和ＨＳＰ７０阳性率均明显地低于未分化和有淋巴结转移的胃癌。结论ＨＳＰ６０和ＨＳＰ７０的表达可能与胃癌临床病理特征、生物学行为和预后有较密切的关系，两者可能是反映胃癌生物学行为和预后的重要标记物。
Objective To study the expression and significance of HSP60 and HSP70 in gastric cancer. Methods Paraffin-embedded gastric cancer tissues were sectioned and observed by ABC immunohistochemical staining. Results The positive rates of HSP60 and HSP70 were 56% and 64% in 50 cases of gastric cancer. The positive rate of HSP60 and HSP70 in gastric cancer with high differentiation and no lymph node metastasis were significantly lower than those in undifferentiated and lymph node metastasis. Conclusion The expression of HSP60 and HSP70 may be closely related to the clinicopathological features, biological behavior and prognosis of gastric cancer, and both may be important markers reflecting the biological behavior and prognosis of gastric cancer.