论文部分内容阅读
目的：了解单用米索前列醇阴道给药在足月妊娠引产中的效果并与卡前列由酯（PG05）及催产素进行比较。方法：320例单胎头位孕妇随机分为三组：米索组（n＝110）、PG05组（n＝110）、催产素组（n＝100）。米索前列醇及PG05均为阴道给药。米索前列醇每次50μg，每3小时一次，总量200μg。PG05每次0．1mg，用药间隔24小时，总量0．3mg。结果：术索组引产成功率（97．3％）明显高于PG05组（89．1％）及催产素组（81．0％），（P＜0．05和P＜0．001）。产程中需加用催产素的病例米索组（1．8％）明显低于PG05组（45．6％）（P＜0．001）。三组剖宫产率、胎儿窘迫率、1分种APgar≤7分率及子宫内膜炎发生率比较，差异无显著性。Bishop≤5分，米索组及PG05组引产成功率分别为97．7％和92．2％，明显高于催产素组（42．6％）（P＜0．001）；Bishop≥6分，三组引产成功率比较差异无显著性（P＞0．05）。结论：米索前列醇阴道局部给药用于晚期妊娠引产是安全、简便、有效的。
OBJECTIVE: To understand the effect of vaginal administration of misoprostol alone in induced labor of full-term pregnancy and to compare it with prepro-ester (PG05) and oxytocin. Methods: A total of 320 pregnant women with single fetal head were randomly divided into three groups: misoprostol (n = 110), PG05 group (n = 110) and oxytocin group (n = 100). Misoprostol and PG05 are vaginally administered. Misoprostol 50μg each time, every 3 hours, the total 200μg. PG05 each 0.1mg, medication interval of 24 hours, the total amount of 0.3mg. Results: The success rate of induction of labor in operation group (97.3%) was significantly higher than that in PG05 group (89.1%) and oxytocin group (81.0%) (P <0.05 and P <0.001). Oxytocin in the labor course required cases of misoprostol (1.8%) was significantly lower than the PG05 group (45.6%) (P <0.001). Three groups of cesarean section rate, fetal distress rate, 1 point APgar≤7 score and the incidence of endometritis, the difference was not significant. Bishop≤5, the success rates of misoprostol and PG05 were 97.7% and 92.2% respectively, significantly higher than that of oxytocin (42.6%) (P <0.001); Bishop≥6 There was no significant difference between the three groups in the success rate of induction of labor (P> 0.05). Conclusion: Topical misoprostol vaginal delivery for late pregnancy induction of labor is safe, simple and effective.