血浆环核苷酸在非胰岛素依赖型糖尿病治疗前后的变化

• 作 者: 崔裕祥 宁英远 朱秀贞 倪安民 田林红 任建功 雷天光 张宏刚 王亦秋 陈雪红 李雨林 秦琳
• 机 构: 兰医二院内分泌组,兰医二院内分泌组,兰医二院内分泌组,兰医二院内分泌组,兰医二院内分泌组,兰医二院内分泌组,兰医二院内分泌组,兰医二院内分泌组,兰医二院同位素科,兰医二院同位素科,兰医二院同位素科,甘
• 出 处: 兰州医学院学报
• 发表日期: 1991年03期
• 关键词: NIDDM 环核苷酸 血浆 空腹 降糖作用 胰岛素 血糖 血浆含量 降血糖药物 病人治疗

本文对82例NIDDM型病人治疗前后系统的观察了空腹和餐后2小时血浆cAMP、cGMP、INS、FBG的含量变化,并对比分析,结果表明:cAMP、cGMP、INS、FBG治疗后无论空腹或餐后2小时,血浆含量均有非常显著性差异(P<0.001)cGMP较治疗前升高近三倍。上述结果提示:cAMP、cGMP与NIDDM型发展有关,经系统治疗后,使体内胰岛素的降糖作用提高,尤其是cGMP可能成为判断NIDDM型病情变化的敏感指标。

In this paper, 82 cases of NIDDM patients before and after treatment were observed fasting and 2 h postprandial plasma cAMP, cGMP, INS, FBG content changes, and comparative analysis, the results showed that: cAMP, cGMP, INS, FBG treatment regardless of fasting or At 2 hours postprandial, there was a very significant difference in plasma levels (P <0.001). CGMP increased nearly three-fold after treatment. The above results suggest that cAMP and cGMP are related to the development of NIDDM type. After systemic treatment, the hypoglycemic effect of insulin in the body is improved, especially cGMP may be a sensitive index to judge the change of NIDDM type.