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目的探讨影响小儿绿脓杆菌败血症病死率的因素。方法回顾性分析1991～2003年间中山医科大学附属第一医院收治的16例14岁以下绿脓杆菌败血症患儿的临床资料。结果发热和腹泻为最常见的初始症状。病死率与性别、年龄、感染途径、是否化疗和使用激素、白细胞数无关(P>0.05),而与基础疾病的严重程度、有无严重并发症、有无低钠血症、高血糖症、血小板减少及有无敏感抗生素联合用药有关(P<0.05)。结论绿脓杆菌败血症是免疫功能低下患儿的常见危重并发症之一,病死率极高,早期经验性联合应用抗绿脓杆菌抗生素可能在一定程度上降低病死率。
Objective To investigate the factors affecting the mortality of Pseudomonas aeruginosa septicemia in children. Methods The clinical data of 16 cases of Pseudomonas aeruginosa sepsis under 14 years old admitted to the First Affiliated Hospital of Sun Yat-sen University from 1991 to 2003 were retrospectively analyzed. Results Fever and diarrhea were the most common initial symptoms. Mortality and sex, age, route of infection, whether chemotherapy and the use of hormones, white blood cell count has nothing to do (P> 0.05), and the severity of underlying diseases, with or without serious complications, with or without hyponatremia, hyperglycemia, Thrombocytopenia and whether the combination of sensitive antibiotics (P <0.05). Conclusions Pseudomonas aeruginosa sepsis is one of the common and critical complications in immunocompromised children. The mortality rate is very high. Early empirical combination of anti-Pseudomonas aeruginosa antibiotics may reduce the mortality rate to a certain extent.