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目的:观察前列地尔治疗失代偿期肝硬化的疗效。方法:对2007年2月到2008年2月入院的失代偿期肝硬化期肝硬化患者,按入院次序,查阅随机数字表分为治疗组和对照组,均给予支持、保肝、利尿治疗,治疗组加输前列地尔100μg+5%葡萄糖液250 mL,每日1次,疗程2周。以治疗前后ALT,AST,前白蛋白,24小时尿量,腹围,B超下腹水深度为观察指标。结果:治疗2周后,治疗组与对照组比较,AST,ALT,腹围及腹水深度显著下降,而前白蛋白及24小时尿量显著升高。结论:前列地尔治疗失代偿期肝硬化疗效显著,副作用少。值得临床推广应用。
Objective: To observe the efficacy of prostaglandin in the treatment of decompensated cirrhosis. Methods: Patients with cirrhosis of liver cirrhosis who were admitted to hospital from February 2007 to February 2008 were divided into treatment group and control group according to admission order and random number table. All patients were given support, liver protection and diuresis , Treatment group plus alprostadil 100μg + 5% glucose solution 250 mL, day 1, treatment for 2 weeks. Before and after treatment with ALT, AST, prealbumin, 24-hour urine output, abdominal circumference, B ultrasound ascites depth as the observation. Results: After 2 weeks of treatment, the levels of AST, ALT, abdominal circumference and ascites decreased significantly in the treatment group compared with the control group, while the albumin and 24-hour urine output increased significantly. Conclusion: Alprostadil treatment of decompensated cirrhosis with significant effect, less side effects. Worthy of clinical application.