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从卡那霉素B衍生的3,4-双脱氧卡那霉素B(DKB)是一个抗绿脓杆菌的新氨基糖苷类抗生素,已知它有肾毒性,本文用大鼠作模型比较它与丁胺卡那霉素(AMK)、艮他霉素(GM)三个氨基糖苷类抗生素对肾脏的毒性。该实验详细报道了实验动物的分组,给药方法以及鉴定肾毒性的指标等。作者取 225g～250g雄性大鼠,随机分成10组,每组16只。对照1组皮下注射1ml生理盐水;2、3、4组为AMK组,剂量分别为50、150、450mg/kg/日;5、6、7组为DKB组,剂量为12、40、
3,4-dideoxykanamycin B (DKB) derived from kanamycin B is a new aminoglycoside antibiotic against Pseudomonas aeruginosa, which is known to have nephrotoxicity and is compared here with rat model And amikacin (AMK), gentamicin (GM) three aminoglycoside antibiotics on the toxicity of the kidneys. The experiments reported in detail the grouping of experimental animals, methods of administration and identification of indicators of renal toxicity. The authors take 225g ~ 250g male rats were randomly divided into 10 groups, 16 in each group. The control group 1 was subcutaneously injected with 1 ml of normal saline; groups 2, 3, and 4 were AMK, the doses were 50,150,450 mg / kg / day; 5,6,7 were DKB groups,