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阿克拉霉素A在临床上是最有前途的抗生素。在日本和法国的第Ⅱ期临床研究结果证明,本品对急性白血病、淋巴肉瘤及胃、胰腺、肠、卵巢、肺和膀胱的转移性肿瘤具有明显疗效。对肝癌亦有良好效果。在临床上,本品的重要特点是对柔红霉素产生获得性耐药性的肿瘤细胞仍有效。阿克拉霉素A为具有弱碱性的黄色粉末,不溶于水,其盐酸盐易溶于水。本品溶液在酸性和中性中呈红色,在碱性中为紫红色。当加入浓硫酸时,呈红桂皮色;在加入浓碱时,变为
Aclacinomycin A is clinically the most promising antibiotic. The results of Phase II clinical studies in Japan and France demonstrate that this product has a significant effect on acute leukemia, lymphosarcoma and metastatic tumors of stomach, pancreas, intestine, ovary, lung and bladder. Liver cancer also has good results. In clinical practice, the important feature of this product is that it is still effective for daunomycin-producing tumor cells with acquired drug resistance. Aclacinomycin A is a weakly alkaline yellow powder that is insoluble in water and its hydrochloride is readily soluble in water. The solution is acidic and neutral red, alkaline purple. When adding concentrated sulfuric acid, red cinnamon color; when adding concentrated alkali, becomes