论文部分内容阅读
目的研究前列地尔脂微球载体制剂(Lipo-PGE1,商品名:凯时)对急性有机磷农药中毒患者急性肝损伤的保护作用。方法将60例重度有机磷农药中毒患者随机分为2组,每组30例。对照组(n=30)给予洗胃、氯磷定、阿托品及对症处理;治疗组在对照组治疗基础上加用Lipo-PGE1注射液10μg/d静脉滴注,连续7 d。同时监测肝功能。结果治疗组治疗3、7 d后丙氨酸转氨酸(ALT)、天冬氨酸转氨酶(AST)及总胆红素(TBil)值较对照组明显下降,差异有统计学意义(P<0.05),临床症状改善更明显。结论 Lipo-PGE1对有机磷农药中毒患者急性肝损伤具有保护作用。
Objective To study the protective effect of alprostadil liposome-loaded microspheres preparation (Lipo-PGE1, trade name Kaixishi) on acute liver injury in patients with acute organophosphorus pesticide poisoning. Methods Sixty patients with severe organophosphorus pesticide poisoning were randomly divided into two groups (n = 30 in each group). The control group (n = 30) was given gastric lavage, chlorophosphorus, atropine and symptomatic treatment. The treatment group was given Lipo-PGE1 injection 10μg / d on the basis of the control group for 7 days. Simultaneous monitoring of liver function. Results The levels of ALT, AST and TBil in the treatment group decreased significantly compared with the control group at 3 and 7 days after treatment (P < 0.05), clinical symptoms improved more significantly. Conclusion Lipo-PGE1 has a protective effect on acute liver injury in patients with organophosphorus pesticide poisoning.