Extensive Studies on the AlEt3/THF-Promoted Diastereoselec-tive Tandem Rearrangement/Reduction of a-

• 作 者: 李心 王保民 赵学智 高栓虎 涂永强 李得润
• 机 构: Department of Chemistry & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lan
• 出 处: Chinese Journal of Chemistry
• 发表日期: 2004年10期
• 关键词: alcohols Quaternary quaternary afford rearrangement protected methanol aromatic

A facile and highly diastereoselective method for the construction of 2-quaternary 1,3-amino alcohols and 1,3-diols has been developed on the basis of the AlEt3/THF-promoted tandem rearrangement/reductive reaction of a-hydroxy (amino) aziridines (epoxides). The progressive achievement in this article included that both 2-epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected.

A facile and highly diastereoselective method for the construction of 2-quaternary 1,3-amino alcohols and 1,3-diols has been developed on the basis of the AlEt3 / THF-promoted tandem rearrangement / reductive reaction of a-hydroxy (amino) The progressive achievement in this article included that both both 2-epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected.