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1临床资料4例中,男3例,女1例,年龄4～8岁.4例因“上下呼吸道感染”服用新速效感冒片(北京制药厂生产),0.5～1片/次,2～3次/d,服药总量最少半片,最多5片.服药30min～2h出现中枢神经系统症状,3例表现嗜睡、多汗、幻觉、幻视、恐惧、睡眠障碍等症,2例反复短暂肢体抽搐,伴意识丧失.4例既往无惊厥及癫痫家族史.3例查脑电地形图,2例正常,1例轻微异常(1个月后复查结果正常)1例肝功、心电图正常.4例停药后经一般治疗,分别在4～24h内中枢神经系统症状逐渐消失,随访1个月无1例留有后遗症.典型病例:例1,男,4岁.因感冒发烧,家长将新速效感冒片当退热药喂服,1片/次,48h共服5片.首次服药后30min患儿出现嗜睡、多汗.第二次服药后1～2h内相继出现嗜睡、神志恍惚、少语、神志不清、双手阵发性握拳式抽动、上肢屈曲、面色苍白,抽搐持续约1min自行缓解入睡,醒后如常.随后3次服药,除上述症状外还有幻觉、幻视、兴奋、语言不清及失眠等症.症状持续时间逐渐延长,最长12h.停药48h来院就诊.体检:体重17kg,神志清,对外界刺激反应灵敏.咽赤,心肺腹(一).肌张力正
1 clinical data in 4 cases, 3 males and 1 females, aged 4 to 8 years old .4 cases of “upper and lower respiratory tract infection” taking new available cold tablets (Beijing Pharmaceutical Factory production), 0.5 to 1 / 3 times / d, taking a total of at least half a tablet, a maximum of 5. Taking 30min ~ 2h central nervous system symptoms, 3 cases of lethargy, hyperhidrosis, hallucinations, hallucinations, fear, sleep disorders embolism, 2 cases of repeated short limbs Convulsions, loss of consciousness, 4 cases of family history of absence of seizures and epilepsy, 3 cases of EEG topography, 2 cases of normal, 1 case of minor abnormalities (1 month after the review was normal) 1 case of liver function, normal ECG.4 Cases after treatment by the general treatment, respectively, in 4 ~ 24h central nervous system symptoms gradually disappear, 1 month follow-up without 1 cases of sequelae. Typical cases: 1 male, 4 years old due to flu and fever, parents will be new Quick cold tablets when antipyretics fed, 1 / time, 48h total of 5. 30 minutes after the first medication children drowsiness, sweating.After the second dose within 1 ~ 2h have lethargy, trance, less Language, confusion, paroxysmal fist clenched hands, upper limb flexion, pale, convulsions continued to about 1min to ease their sleep, woke up as usual. Then 3 times Medicine, in addition to the above symptoms in addition to hallucinations, hallucinations, excitement, unclear language and insomnia embolism symptoms gradually extended, up to 12h. Withdrawal 48h to the hospital. Physical examination: weight 17kg, clear mind, to the outside world to stimulate Responsive. Pharynx red, cardiopulmonary abdomen (a). Muscle tension is positive