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宿主对链球菌抗原的异常免疫应答(体液免疫、细胞免疫或两者同时存在)是易感个体发生风湿热的病因。为了观察风湿热与风湿性心脏病患者的免疫应答,作者选择了27名急性风湿热、11名慢性风湿性心脏病和23名健康人作对照,进行羊红细胞玫瑰花试验,羊红细胞抗体补体玫瑰花试验,并用胶乳凝集抑制法和补体依赖淋巴细胞玫瑰花抑制法(EAC法),测定血液中免疫复合物,用免疫萤光技术检测自身抗体。测定结果:急性风湿热患者,T淋巴细胞绝对值高于慢性风湿性心脏病人和对照组,因其平均总淋巴细胞数非常高(4,088±3,488细胞/mm~3)。急性风湿热病人的T淋巴细胞平均百分率为39±12,而
Host abnormal immune response to streptococcal antigen (humoral immunity, cellular immunity or both) is the cause of rheumatic fever in susceptible individuals. In order to observe the immune response of patients with rheumatic fever and rheumatic heart disease, the authors selected 27 patients with acute rheumatic fever, 11 patients with chronic rheumatic heart disease and 23 healthy people as controls and conducted a test of rose blood cells in sheep with red blood cells antibody complement rose Flower test, and latex agglutination inhibition and complement-dependent lymphocyte inhibition rose method (EAC method), the determination of immune complexes in the blood, the use of immunofluorescence detection of autoantibodies. The results showed that the absolute value of T lymphocytes in patients with acute rheumatic fever was higher than that in patients with chronic rheumatic heart disease and the control group because the average total number of lymphocytes was very high (4,088 ± 3,488 cells / mm ~ 3). The average percentage of T lymphocytes in patients with acute rheumatic fever was 39 ± 12,