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为探讨肿瘤切除对肺癌患者抗肿瘤免疫活性的影响，用间接免疫荧光染色流式细胞计数分析技术检测了３６例肺癌患者外周血淋巴细胞表型和ＮＫ细胞的治疗变化。结果患者ＣＤ３、ＣＤ４细胞、ＮＫ细胞数量及ＣＤ４／ＣＤ８比值均低于正常对照，ＣＤ２０细胞增多。手术切除肿瘤后，肺癌无转移的患者ＣＤ３、ＣＤ４细胞、ＮＫ细胞数量及ＣＤ４／ＣＤ８明显增高，接近正常水平，肿瘤有转移的病例ＮＫ细胞升高较少，与术前无统计学差异。提示肿瘤无转移的患者免疫抑制轻，其预后好于己有转移的患者，肿瘤切除可促使免疫功能恢复
To investigate the effect of tumor resection on the anti-tumor immune activity of lung cancer patients, the peripheral blood lymphocyte phenotype and NK cell treatment changes in 36 lung cancer patients were detected by indirect immunofluorescence staining flow cytometry analysis. Results The number of CD3, CD4 cells, NK cells and the ratio of CD4/CD8 were lower than normal controls, and CD20 cells increased. After surgical removal of the tumor, the numbers of CD3, CD4 cells, NK cells, and CD4/CD8 in patients with non-metastasis lung cancer were significantly higher, approaching normal levels, and there was less increase in NK cells in patients with tumor metastases, which was not statistically different from preoperative ones. Patients with no metastasis suggest that the immunosuppression is mild and their prognosis is better than those with metastases. Tumor resection can promote recovery of immune function.