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目的 探讨原发性肝癌术后抗复发对策,及以再切除为主的综合治疗措施的远期疗效。方法 对我院自1960 年1 月至1996 年5 月间162 例原发性肝癌术后复发行再切除者的临床特点、手术方法和预后进行回顾性分析。结果 全组1、3、5、10 年总生存率分别为96.8% 、66.7 % 、43 .6% 和21.8% 。中位生存期3 年9 个月,平均生存期4 年5 个月;其中肝内复发组126 例术后1、3、5、10 年生存率分别为99.2% 、71.3% 、46.6%和19.1% ,二次肝切除术后1、3、5 年生存率分别为83.5 % 、38.2% 和19 .6 % ,三次肝切除术后1 、3、5 年生存率分别为94.7% 、44 .9 % 和25.0% ;肝外转移组30 例首次肝切除术后1、3、5 年生存率分别为89 .7% 、61.0 % 和32.6% ,二次肝外转移灶切除术后1、3、5 年生存率分别为75 .4% 、29.0 % 和15.6% ;兼行肝内复发癌和肝外转移灶切除组共6 例,现存活3 例,手术至今分别为1 年10 个月,3 年9 个月和9 年9 个月。另3 例相继于术后3年11 个月、5 年8 个月和6 年11 个月死亡。结论 复发的原因与门静脉癌栓及肿瘤多中?
Objective To investigate the anti-recurrence strategies for primary liver cancer after operation and the long-term efficacy of comprehensive treatment measures based on re-excision. Methods The clinical features, surgical methods and prognosis of 162 patients undergoing recurrent resection of primary liver cancer from January 1960 to May 1996 were retrospectively analyzed. Results The overall 1-, 3-, 5-, and 10-year overall survival rates were 96.8%, 66.7 %, and 43. 6% and 21.8%. The median survival period was 3 years and 9 months, and the average survival time was 4 years and 5 months. Among them, 126 patients in the intrahepatic recurrence group had a postoperative survival rate of 99.2% and 71.3% at 1, 3, 5 and 10 years, respectively. At 46.6% and 19.1%, the 1-, 3-, and 5-year survival rates after secondary hepatectomy were 83.5%, 38.2%, and 19, respectively. At 6 %, the 1-, 3-, and 5-year survival rates after three hepatectomy were 94.7% and 44 respectively. Ninety percent and 25.0% of the patients who received extrahepatic metastasis had a 1-, 3-, and 5-year survival rate of 30 after the first liver resection. 7%, 61.0%, and 32.6%. The survival rate after resection of secondary extrahepatic metastases was 1, 3, and 5 years, respectively. 4%, 29.0%, and 15.6%; Intrahepatic recurrent cancer and extrahepatic metastases resection group consisted of 6 cases, and 3 cases survived. The operation so far has been 1 year 10 months, 3 years 9 months and 9 years and 9 months. The other 3 patients died 3 years 11 months, 5 years 8 months and 6 years 11 months after surgery. Conclusion The reasons for recurrence and portal vein tumor emboli and tumors are many?