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皮质类固醇(激素)治疗支气管哮喘,应严格掌握适应症,因不能根治哮喘,副作用大。用之得当可以转危为安,用之不当可得不良后果。注意掌握适应症,避免副作用;合理用药,减少激素依赖性,是目前激素使用的重要课题。一、适应症: 1.多用于哮喘急性重症发作; 2.顽固慢性发作,支气管舒张药物不能缓解者; 3.估计有肾上腺皮质功能不全。皮质类固醇治疗哮喘的药理作用:(1)稳定溶酶体膜,有抗炎、降低细血管壁的通透性。(2)抑制磷酸二酯酶的活性。阻止腺甙酸环化酶(CAMP)转化为5磷酸腺甙(5AMP),稳定肥大细胞内腺甙酸环化
Corticosteroids (hormones) for the treatment of bronchial asthma, should be strictly controlled indications, because they can not cure asthma, side effects. Proper use can be endangered, use improperly available adverse consequences. Attention to master indications, to avoid side effects; rational use of drugs to reduce hormone dependence, is an important issue of hormone use. First, the indications: 1. Used for acute exacerbation of asthma; 2. Stubborn chronic attack, bronchodilator drugs can not be relieved; 3. Estimated adrenal insufficiency. The pharmacological effects of corticosteroid treatment of asthma: (1) stable lysosomal membrane, anti-inflammatory, reducing the permeability of the thin blood vessel wall. (2) inhibit phosphodiesterase activity. Prevents the conversion of adenosine cyclase (CAMP) to adenosine 5-adenosine (5 AMP), stabilizes mast cell adenosine cycle