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急性出血性肠炎或称坏死性小肠结肠炎是临床常见重症,其主要发病环节尚未明确。1965年我国祝寿河教授根据临床分析提出:该病是以肠为主的急性微循环障碍性疾病。为从实验医学角度进行探讨,必需有相应的动物模型,但国内外尚未见报导。我们受急性出血性肠炎的发病过程及肠的节段性病理改变与家兔皮肤施瓦茨曼现象有许多相似之处的启发,沿此线索建立了家兔出血性肠炎模型。 实验Ⅰ组5只,小肠浆膜下注溶于5毫升生理盐水的大肠杆菌内毒素1毫克/公斤,24小时后观察局部肠管外观基本正常,静注内毒素3毫克/公斤后,5只中3只于半小时左右可见以原注内毒素肠管为中心,约10厘
Acute hemorrhagic enteritis or necrotizing enterocolitis is a common clinical critically ill, the main pathogenesis is not yet clear. In 1965, Professor Zhu Shouhe of our country proposed based on the clinical analysis that the disease is an acute microcirculation disorder with intestine as the main part. In order to explore from the perspective of experimental medicine, there must be a corresponding animal model, but no reports have been reported at home and abroad. We are inspired by the similarities between the pathogenesis of acute hemorrhagic enteritis and segmental pathological changes in the intestine and the Schwartz phenomenon in rabbit skin. Based on this, we established a model of haemorrhagic enteritis in rabbits. In experiment group I, 5 animals were injected with 5 mg saline into E. coli endotoxin 1 mg / kg. After 24 hours, the local bowel appearance was observed. After endotoxin was treated with 3 mg / kg endotoxin, 5 3 in about half an hour or so visible to the original note endotoxin intestinal centers, about 10%