【摘 要】
：
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5\'-O-galloyl)-α-L-arabinofuranoside (1)
【机 构】
：
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmace
论文部分内容阅读
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5\'-O-galloyl)-α-L-arabinofuranoside (1), 6-methylquercetin 7-O-β-D-glucopyranoside (2), one new methylchromone glycoside, 7-O-(4\', 6\'-digalloyl)-β-D-glucopyranosyl-5-hydroxy-2-methylchromone (3), together with three known compounds (4-6). The structures of these isolated compounds were established on the basis of 1D and 2D NMR techniques and chemical methods. The anti-inflammatory activities of the compounds 1-6 were evaluated for their inhibitory effects against cyclooxygenases-1 and-2 in vitro. Compounds 1-6 showed potent COX-1 and COX-2 inhibiting activities in vitro with IC50values ranging from 1.95 to 5.54 μmol·L-1and ranging from 1.01 to 2.27 μmol·L-1, respectively.
其他文献
Two cyclopeptides,celogentin L (1) and its epimer lyciumin A (2) were firstly isolated from Celosia argentea L..The planar structures of the two compounds were fully determined by spectroscopic data,including 1D-,2D-NMR,and HR-ESI/MS.The absolute configur
Nineteen preschisanartane-type schinortriterpenoids (SNTs),among which eleven ones were previously undescribed,were isolated from two Schisandra species,S.sphaerandra and S.rubriflora.Their structures were determined using 1D and 2D NMR spectroscopic anal
One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5 S-hydroxynorvalineS-Ile (2), and two naturally occurring diketopiperazines, 3 S-hydroxylcyclo (S-Pro-S-Phe) (3) and cyclo (S-Phe-S-Gln) (4), together with three
Diabetic nephropathy (DN) is a leading cause of renal failure,contributing to severe morbidity and mortality in diabetic patients.Umbelliferae (Umb) has been well characterized to exert protective effects in diabetes.However,the action and mechanism of Um
Oleanolic acid (OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970 s. In our previous study, we observed that OA
To investigate the effect of Yiqi Wenyang (YQWY) decoction on reversing cardiac hypertrophy induced by the transverse aortic constriction (TAC).Wistar rats aged 7-8 weeks were subjected to TAC surgery and then randomly divided into 4 groups (n =5/group):S
Dogwood fruits are a valuable source of active ingredients,such as phenolic compounds,vitamin C,iridoids,flavonoids and anthocyanins.Plant extracts and substances derived from latin Cornus mas L.exhibit not only strong antibacterial but also antioxidant a
In the present study, three compounds were isolated from Argyreia acuta, among them, compounds 1 and 2 were new and Compounds 1 and 3 were isomers. They were separated by several types of columns, such as normal phase, RP, size exclusion and preparative H
The present study was designed to further investigate the C21 steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known co
Tanreqing (TRQ),a traditional Chinese medicine (TCM) formula,can alleviate liver injury and improve liver function.Its pharmacological mechanisms of actions are still unclear due to its complex components and multi-target natures.Metabolomic study is an e