【摘 要】
：
Oleanolic acid (OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970 s. In our previous study, we observed that OA
【机 构】
：
Jiangsu Key Laboratory of Drug Screening and Jiangsu Key Laboratory of Drug Discovery for Metabolic
论文部分内容阅读
Oleanolic acid (OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970 s. In our previous study, we observed that OA could ameliorate hyperlipidemia in animal models. In the present study, we conducted a small-scale clinical trial to evaluate the hypolipidemia effect of OA in hyperlipidemic patients. Hyperlipidemic patients were administrated with OA for four weeks (4 tablets once, three times a day). The blood samples of the patients were collected before and after OA treatment. The biological parameters were measured. Furthermore, three patients\' blood samples were studied with DNA microarray. After OA administration, the TC, TG, and HDLC levels in serum decreased significantly. DNA microarray analysis results showed that the expressions of 21 m RNAs were significantly changed after OA treatment. Bioinformatics analysis showed 17 m RNAs were up-regulated and 4 m RNAs were down-regulated significantly after OA treatment. Five m RNAs (CACNA1 B, FCN, STEAP3, AMPH, and NR6 A1) were selected to validate the expression levels by q RT-PCR. Therefore, OA administration differentially regulated the expression of genes involved in lipid metabolism. The data showed a clinical evidence that OA could improve hyperlipidemia and also unveiled a new insight into the molecular mechanisms underlying the pharmacological effect of OA on hyperlipidemia.
其他文献
Dendrobium officinale is not only an ornamental plant,but also a valuable medicinal herb that is widely used in traditional Chinese medicine.However,distinguishing D.officinale from other Dendrobium species is usually a difficult task.In this study,we dev
The present study was designed to improve storage stability and oral bioavailability of Ganneng dropping pills (GNDP)by transforming lignans of Herpetospermum caudigerum (HL) composed of herpetrione (HPE) and herpetin (HPN) into nanosuspension (HL-NS),the
Two new isomeric modified tripeptides,aspergillamides C and D (compounds 1 and 2),together with fifteen known compounds (compounds 3-17),were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.The structures of the new compound
Modified Da-chai-hu Decoction (MDD),a traditional Chinese medicinal formulation,which was empirically generated from Da-chai-hu decoction,has been utilized to treat severe acute pancreatitis (SAP) for decades.The aim of the present study was to explore it
Twenty-one lignans including three new ones (1,2 and 13) were isolated from Justicia procumbens.The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis.These compounds were evaluated for their cyt
Naodesheng (NDS) formula,which consists of Rhizoma Chuanxiong,Lobed Kudzuvine,Carthamus tinctorius,Radix Notoginseng,and Crataegus pinnatifida,is widely applied for the treatment of cardio/cerebrovascular ischemic diseases,ischemic stroke,and sequelae of
Two cyclopeptides,celogentin L (1) and its epimer lyciumin A (2) were firstly isolated from Celosia argentea L..The planar structures of the two compounds were fully determined by spectroscopic data,including 1D-,2D-NMR,and HR-ESI/MS.The absolute configur
Nineteen preschisanartane-type schinortriterpenoids (SNTs),among which eleven ones were previously undescribed,were isolated from two Schisandra species,S.sphaerandra and S.rubriflora.Their structures were determined using 1D and 2D NMR spectroscopic anal
One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5 S-hydroxynorvalineS-Ile (2), and two naturally occurring diketopiperazines, 3 S-hydroxylcyclo (S-Pro-S-Phe) (3) and cyclo (S-Phe-S-Gln) (4), together with three
Diabetic nephropathy (DN) is a leading cause of renal failure,contributing to severe morbidity and mortality in diabetic patients.Umbelliferae (Umb) has been well characterized to exert protective effects in diabetes.However,the action and mechanism of Um