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目的：观察通腑固肾灌肠剂对腺嘌呤致大鼠慢性肾衰的影响。方法：连续喂养０．５％腺嘌呤使ＳＤ大鼠产生氮质血症、毒素蓄积等类似于人慢性肾衰的症状。两周后，治疗组大鼠每天用中药通腑固肾灌肠剂（１３，６．５ｇ·ｋｇ－１）灌肠连续２周后测定大鼠血尿素氮（（ＢＵＮ），肌酐（Ｓｃｒ），ＲＢＣ，ＨＧＢ，ＨＣＴ及肾脏病理学检查。结果：通腑固肾灌肠剂能明显改善大鼠肾衰症状，用药２周后使ＢＵＮ，Ｓｃｒ水平明显降低（Ｐ＜０．０１），有升ＲＢＣ，ＨＧＢ，ＨＣＴ趋势，给药组与模型组大鼠比较，肾重量减轻（Ｐ＜０．０１），肾组织内结晶沉积物减少（Ｐ＜０．０１），纤维组织增生减轻。结论：通腑固肾灌肠剂对大鼠肾衰有明显治疗效果。
Objective: To observe the effect of Tongqiao Gushen enema on chronic renal failure induced by adenine in rats. METHODS: Continuous feeding of adenine 0.5% produced azotemia and toxin accumulation similar to that of chronic renal failure in SD rats. Two weeks later, rats in the treatment group were treated with traditional Chinese medicine Tongfu Guren Enema (13, 6.5g·kg-1) for 2 consecutive weeks to determine blood urea nitrogen (BUN), creatinine (Scr), and RBC. , HGB, HCT and renal pathological examination.Results: Tongqiao Gushen enema can significantly improve the symptoms of renal failure in rats, and after 2 weeks of treatment, the levels of BUN and Scr are significantly decreased (P<0.01), and RBC is increased. HGB, HCT trend, compared with the model group rats, the kidney weight was reduced (P<0.01), the crystalline sediments in the kidneys were reduced (P<0.01), and the proliferation of fibrous tissue was reduced.Conclusion: Tongyu Gu Shen enema has obvious therapeutic effect on renal failure in rats.