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[目的]探讨NOB1在宫颈鳞癌组织中的表达及其与临床病理因素和预后的关系。[方法 ]采用免疫组织化学SP法检测157例宫颈鳞癌、54例宫颈上皮内瘤样病变(CIN)及42例宫颈正常组织中NOB1的表达。[结果 ]宫颈正常组织、CIN组织和宫颈鳞癌组织NOB1的表达阳性率分别为5.0%、29.6%和73.8%,差异有统计学意义(P<0.001)。NOB1在宫颈癌中的表达与肿瘤分化程度及是否淋巴结转移有关(P<0.05);而与患者年龄、肿瘤直径、临床病理分期及浸润深度无明显相关(P>0.05)。NOB1阳性表达患者的5年累积生存率较阴性表达者低(P<0.01)。[结论]NOB1的表达与宫颈鳞癌的临床病理因素及预后有一定关系,其高表达可能在宫颈癌发生、发展中起重要作用,并很可能成为潜在的治疗靶点及预测宫颈癌预后的有价值的分子标志物。
[Objective] To investigate the expression of NOB1 in cervical squamous cell carcinoma and its relationship with clinicopathological factors and prognosis. [Method] The expressions of NOB1 in 157 cases of cervical squamous cell carcinoma, 54 cases of cervical intraepithelial neoplasia (CIN) and 42 cases of cervical normal tissue were detected by immunohistochemical SP method. [Results] The positive expression rates of NOB1 in cervical normal tissue, CIN tissue and cervical squamous cell carcinoma were 5.0%, 29.6% and 73.8%, respectively, with statistical significance (P <0.001). The expression of NOB1 in cervical cancer correlated with tumor differentiation and lymph node metastasis (P <0.05), but not with age, tumor diameter, clinicopathologic stage and depth of invasion (P> 0.05). The 5-year cumulative survival rate of NOB1-positive patients was lower than that of negative ones (P <0.01). [Conclusion] The expression of NOB1 is closely related to the clinicopathological factors and prognosis of cervical squamous cell carcinoma. The high expression of NOB1 may play an important role in the occurrence and development of cervical cancer and may be a potential therapeutic target and predict the prognosis of cervical cancer Valuable molecular marker