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羟氨喹是治疗曼氏血吸虫病的首选药物。作者采用每次15mg/kg日服2次的一日疗法门诊给药,在2年半时间里治疗了4,000多例曼氏血吸虫病人。患者于早晨门诊时服首剂药,当晚临睡前服第2剂药。治愈率达80%以上,一般药物副反应轻微。然而在1984年头2个月,许多病人诉说服药后恶心和腹痛加重。其中6例出现严重副反应,包括严重呕吐、头痛、昏厥、严重健忘症、对空间和时间定向障碍、精神紊乱和剧烈腹痛。有1例
Hydroxyquramine is the drug of choice for the treatment of Schistosoma mansoni. The authors administered a one-day outpatient medication twice daily for 15 mg / kg and treated more than 4,000 patients with Schistosoma mansoni in two and a half years. Patients in the morning outpatient service first dose, the night before going to sleep to take the second dose. Cure rate of 80% or more, the general side effects of drugs minor. However, in the first two months of 1984, many patients complained of nausea and abdominal pain after taking the medication. Six of these patients developed serious adverse reactions including severe vomiting, headache, fainting, severe amnesia, space-and-time disorientation, mental disorders and severe abdominal pain. In 1 case