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作者对25例常规治疗无效并有持续出血的自身免疫性血小板减少症(AT)患者,进行了静脉内输注大剂量IgG的研究。所有患者均曾用过激素和/或细胞毒药物无效。按病期持续16周以内或以外分为两组。①早期组:10例,其中8例为特发性AT,2例AT伴淋巴性白血病和何杰金氏病。4例曾行脾切除术无效,5例在输注IgG后进行脾切除,1例未行脾切除予以高剂量化疗。②晚期组:15例,其中10例为特发性AT,2例AT伴自身免疫性溶血性贫血,2例伴SLE,1例伴少年型类风湿关节炎。5例因多种原因未行脾切除术。免疫球蛋白SRC(Sandozlobulin)0.4g/kg/d,静注,共5天,原治疗不变。结果所有患者在输注IgG期间血小板计数均见增高。两组于输注前后进行比较,结果其均值无显
The authors conducted a study of intravenous infusion of high-dose IgG in 25 patients with autoimmune thrombocytopenia (AT) who had conventional treatment failure and persistent hemorrhage. All patients had used hormone and / or cytotoxic drugs ineffective. According to the duration of disease within 16 weeks or divided into two groups. ① early group: 10 cases, of which 8 cases of idiopathic AT, 2 cases of AT with lymphoid leukemia and Hodgkin’s disease. Four cases had splenectomy was ineffective, five cases were performed splenectomy after the infusion of IgG, one case without splenectomy to high-dose chemotherapy. ② advanced group: 15 cases, of which 10 cases of idiopathic AT, 2 cases of AT with autoimmune hemolytic anemia, 2 cases with SLE, 1 case with juvenile rheumatoid arthritis. Five patients had not undergone splenectomy for a variety of reasons. Immunoglobulin SRC (Sandozlobulin) 0.4g / kg / d, intravenous injection, a total of 5 days, the original treatment unchanged. Results All patients had an elevated platelet count during IgG infusion. The two groups were compared before and after infusion, the results were no significant average