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多巴酚丁胺(dobutamine)是一种β-肾上腺素能受体选择性促效剂,它对心肌梗塞急性期功能不全的左心室具增强收缩力的作用。作者研究10例穿壁性心肌梗塞患者用多巴酚丁胺10gg/kg/min心内膜下灌注与等剂量多巴胺作比较。应用心内膜下生机比值(EUR)、舒张压时间指数对收缩压时间指数比值来估价心内膜下灌注情况。用10μg/kg/min多巴胺时心脏指数平均增高35％;而多巴酚丁胺则用6.75μg/kg/min方能达到该水平。两药增高心率为13％。多巴酚丁胺当肺楔压下降34％时,动脉收缩压增高9.6％;肺楔压维持不变,多巴胺能增加动脉收缩压19％。
Dobutamine is a beta-adrenergic receptor-selective agonist that enhances contractility in the left ventricular dysfunction in the acute phase of myocardial infarction. The authors studied 10 patients with mural myocardial infarction with dobutamine 10gg / kg / min subendocardial perfusion with an equal dose of dopamine for comparison. The subendocardial perfusion was assessed by the ratio of the subendocardial viability ratio (EUR), the diastolic time index to the systolic pressure time index. Cardiac index increased by an average of 35% with 10 μg / kg / min of dopamine; whereas dobutamine was able to reach this level with 6.75 μg / kg / min. Two drugs to increase heart rate was 13%. Dobutamine increased pulmonary arterial systolic blood pressure by 9.6% when pulmonary wedge pressure decreased by 34%; pulmonary wedge pressure remained unchanged and dopamine increased arterial systolic pressure by 19%.