论文部分内容阅读
目的：探讨肿瘤坏死因子在妊高征发病中的作用及与内皮素的关系。方法：采用放射免疫法测定了４６例妊高征患者（妊高征组）和２０例正常晚期妊娠妇女（对照组）血浆肿瘤坏死因子（ＴＮＦ）和内皮素（ＥＴ－１）的质量浓度。结果：妊高征组中、重度患者ＴＮＦ和ＥＴ－１质量浓度明显高于对照组和轻度患者（Ｐ＜０．０５及Ｐ＜０．０１）；产后７２小时两者质量浓度均明显下降。对照组血浆ＴＮＦ与ＥＴ－１质量浓度无相关性，而妊高征组两者的质量浓度呈正相关性（ρ＝０．５１２，Ｐ＜０．００１）。结论：ＴＮＦ对妊高征致病的一个重要环节可能是通过损伤血管内皮，进而引起ＥＴ－１合成和释放增加，导致血管痉挛而发病。
Objective: To investigate the role of tumor necrosis factor in the pathogenesis of pregnancy induced hypertension and its relationship with endothelin. Methods: The plasma concentrations of tumor necrosis factor (TNF) and endothelin (ET-1) were measured in 46 patients with PIH (PIH group) and 20 normal pregnant women (control group) by radioimmunoassay. Results: The concentrations of TNF and ET-1 in severe and severe PIH patients were significantly higher than those in control group and mild patients (P <0.05 and P <0.01). The concentrations of TNF and ET-1 in PIH group were significantly decreased . There was no correlation between plasma TNF and ET-1 concentration in the control group, but there was a positive correlation between the two groups in the PIH group (ρ = 0.512, P <0.001). Conclusion: An important part of the pathogenesis of PIH may be through the injury of vascular endothelium, which in turn leads to the increase of synthesis and release of ET-1, leading to the occurrence of vasospasm.