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我们曾观察到非抗酸剂量的黄腐酸对消炎痛引起的大鼠胃粘膜损伤具有明显的预防作用,设想其机制可能与胃粘膜的前列腺素(PG)有密切关系,本工作进一步观察黄腐酸能否翻转消炎痛对胃粘膜PGE的抑制作用。 另外,我们还曾观察到非抗酸剂量的黄腐酸对无水酒精引起的大鼠胃损伤具有明显的细胞保护作用。无水酒精对胃的损伤可能是直接破坏粘膜细胞而与粘膜的PG无关,本工作也进一步观察黄腐酸预防无水酒精引起的大鼠胃损伤作用中对粘膜PGE有无影响。
We have observed that non-antacid dose of fulvic acid has a significant preventive effect on indomethacin-induced gastric mucosal damage in rats. It is envisaged that its mechanism may be closely related to prostaglandin (PG) in the gastric mucosa. This work further observed yellow Can fulvic acid reverse the inhibitory effect of indomethacin on gastric mucosal PGE. In addition, we have also observed that non-antacid dose of fulvic acid has obvious cytoprotective effect on anhydrous alcohol-induced gastric lesions in rats. The damage of anhydrous alcohol to the stomach may be directly related to the destruction of mucosal cells but not to the PG of the mucous membranes. This work also further investigated whether the effects of fulvic acid on ethanol injury induced by gastric injury in rats have no effect on mucosal PGE.