论文部分内容阅读
局灶性节段性肾小球硬化(FSG)肾移植后经常复发,因而导致移植肾功能丧失的发生率高。治疗通常无效。作者报告用抗炎酸(meclofe-namate)治疗肾移植后的FSG肾病综合征2例。例1 为8岁男性,于1983年12月首次水肿,诊断为肾病综合征。经强的松治疗曾有好转,随后无效。肾活检证实为FSG。1987年3月起采用强的松、静注甲基强的松龙及环磷酰胺等药,但均无效。于1987年6月11日行活体肾移植,所用免疫抑制剂包括环孢素、硫唑嘌呤及强的松。术后第2天血清肌酐(Scr)降至0.8mg/dl,第5天测尿蛋白为18g/d,血清白蛋白降
Focal segmental glomerulosclerosis (FSG) recurrent after renal transplantation, resulting in a high incidence of graft loss. Treatment is usually ineffective. The authors report the use of anti-inflammatory acid (meclofe-namate) in the treatment of FSG nephrotic syndrome after renal transplantation in 2 cases. Example 1, an 8-year-old man, had his first edema in December 1983 and was diagnosed with nephrotic syndrome. After prednisone treatment had improved, then invalid. Renal biopsy confirmed FSG. March 1987 since the use of prednisone, intravenous methylprednisolone and cyclophosphamide and other drugs, but were invalid. In June 11, 1987 living body kidney transplantation, immunosuppressive agents used include cyclosporine, azathioprine and prednisone. Serum creatinine (Scr) was reduced to 0.8 mg / dl on the second day after operation, urinary protein was 18 g / d on the fifth day, serum albumin