论文部分内容阅读
要本实验采用快速点燃致痫模型，对点燃即刻、点燃后２天和７天大鼠海马进行了光镜和超微结构的观察。结果显示：点燃即刻，光镜和电镜下大鼠海马结构正常，功能活动明显增强。点燃后两天，海观内出现明显的神经元变性和脱失。点燃后７天仍有神经元的变性和脱失，但病变程度减轻，正常神经元数点燃２天时有明显增加，同时有大量胶质细胞增生。这些改变揭示，点燃的发生与海马结构损伤无关，点燃后出现的神经元变性是点燃的结果。点燃后动物脑细胞的长期改变可能与点燃后神经元的变性、脱失、神经纤维出芽、突触重建和胶质细胞增生有关。
In this experiment, rapid ignition induced epileptiform model was used to observe the light microscopy and ultrastructure of rat hippocampus immediately after ignition and 2 and 7 days after ignition. The results showed that immediately after ignition, the structure of hippocampus in rats under light and electron microscope was normal and the functional activity was obviously enhanced. Two days after lighting, obvious neuronal degeneration and loss occurred in the sea view. There were still neuronal degeneration and delaying 7 days after ignition, but the degree of lesion was reduced. The number of normal neurons increased obviously when lit for 2 days, and a large number of glial cells hyperplasia. These changes revealed that the occurrence of ignition has nothing to do with the structural damage of the hippocampus, neuronal degeneration after ignition is the result of ignition. Long-term changes in animal brain cells after ignition may be related to degeneration and denervation of neurons after ignition, budding of nerve fibers, synaptic reconstruction and glial cell proliferation.