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自1997年3月至7月,我们采用低剂量基因重组人粒细胞——巨噬细胞集落刺激因子(rhGM-CSF,商品名生白能),治疗肿瘤化疗所致的白细胞减少症,取得了良好的效果.现报告如下:1 材料与方法1.1 一般资料 全组患者45例均经组织学或细胞学确诊为恶性肿瘤,男性30例、女性15例,年龄8～70岁、中位年龄56岁;无明显肝、肾功能损害,无造血功能障碍.其中肺癌10例,恶性淋巴瘤20例,鼻咽癌2例,乳腺癌3例,胃癌2例,结直肠癌2例,头颈部癌3例,软组织及骨肿瘤3例.一般状况评分≥70分.全组病例均采用国内的常规方案化疗.化疗所用药物有环磷酰胺及异环磷酸胺、阿霉素、顺铂或卡铂、足叶乙甙、丝裂霉素、泰素、氮烯咪胺和5-氟脲嘧啶等.以化疗后所致的外周白细胞总数低于3.0×10~9/L者作为使用该药的入组对象.1.2 用药方法 生白能(Leucomax,美国先灵葆雅药厂产品)50μg,皮下注射,每天1次,连用5天.期间不用其它升白药物或输血治疗.
From March to July 1997, we used a low-dose recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF, trade name Shengbai) to treat neutropenia caused by cancer chemotherapy. Good results. The report is as follows: 1 Materials and Methods 1.1 General Information 45 patients in the whole group were diagnosed as malignant tumors by histology or cytology, 30 males and 15 females, aged 8 to 70 years, median age 56 Years old; No obvious liver and kidney function damage, no hematopoietic dysfunction, including 10 cases of lung cancer, 20 cases of malignant lymphoma, 2 cases of nasopharyngeal carcinoma, 3 cases of breast cancer, 2 cases of gastric cancer, 2 cases of colorectal cancer, head and neck There were 3 cases of carcinoma, 3 cases of soft tissue and bone tumor. The general condition score was ≥70 points. All the cases were treated with conventional domestic chemotherapy. Cyclophosphamide and heterocyclic phosphate, adriamycin, cisplatin or cardiotherapy were used for chemotherapy. Platinum, etoposide, mitomycin, paclitaxel, nitidine and 5-fluorouracil, etc. As the use of this drug, the total number of peripheral leukocytes after chemotherapy was lower than 3.0 × 10-9/L. The group of enrolled in.1.2 Medication method Baineng (Leucomax, Schering-Plough US pharmaceutical products) 50μg, subcutaneously, once daily, 5 days without drug or other Shengbai during blood transfusions.