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目的：探讨芳烃羟化酶（AHH）与肺癌遗传易感性的关系。方法；采用AHH直接规定法检测肺癌患者40例、肺癌患者亲属26例及健康人物例血液淋巴细胞中AHH的诱导力。结果：①肺癌组及肺癌患者亲属（一级亲属24人，二级亲属2人）高AHH诱导力型升高（22．5％，15．4％），肺癌组高AHH诱导力型与对照组（6．7％）相比有上升趋势（P＝0.12，x2检验）。②不吸烟者中，肺癌组、肺癌患者亲属及对照组高AHH诱导力者分别达15．4％、ZI％、7．3％，肺＃患者亲属高AHH诱导力型有上升趋势（P二0．2）。③肺癌的相对危险性（OR）与淋巴细胞中AHH的诱导力有关，肺癌亲属中高AHH诱导力的OR值是低AHH诱导力者的2．1倍。结论：肺癌具有遗传易感性，与AHH诱导力密切相关。
Objective: To investigate the relationship between AHRH and genetic susceptibility to lung cancer. Methods: AHH was used to directly detect the induction of AHH in blood lymphocytes from 40 patients with lung cancer, 26 relatives of lung cancer patients, and healthy people. RESULTS: 1 The high AHH-induced increase in lung cancer and lung cancer patients’ relatives (24 first-degree relatives and 2 second-degree relatives) (22.5%, 15.4%), and high AHH-inducing power in lung cancer and control There was an upward trend in the group (6.7%) (P=0.12, x2 test). Among the 2 nonsmokers, lung cancer group, relatives of lung cancer patients and relatives of the control group had high AHH-inducing power of 15.4%, ZI%, and 7.3%, respectively, and the high AHH-inducing power of relatives of patients with lungs had an upward trend (P2). 0.2). 3 The relative risk (OR) of lung cancer was related to the induction of AHH in lymphocytes. The OR of the high AHH-inducing power in lung cancer relatives was 2.1 times that of the low AHH-inducing force. Conclusion: Lung cancer has genetic susceptibility and is closely related to the induction of AHH.