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目的分析肝病患者药品不良反应(ADR)的发生规律,探讨临床合理用药。方法对我院2008年1月—2009年6月收集到的168例ADR报告进行分类统计。结果 168例ADR报告中,涉及药物37种,其中中成药13种(35.14%),肝病辅助治疗药8种(21.62%),抗感染药4种(10.81%),抗病毒药4种(10.81%)等。ADR累及系统以皮肤及其附件损害最多,共79例(47.02%),其次为全身性损害,上报了39例(23.21%),有4例严重的ADR发生。结论应加强对肝病患者ADR的监测工作,以保证临床用药的安全性,有效性。
Objective To analyze the occurrence of adverse drug reactions (ADR) in patients with liver diseases and to explore the clinical rational use of drugs. Methods 168 cases of ADR collected in our hospital from January 2008 to June 2009 were classified. Results Among 168 ADR cases, 37 kinds of drugs were involved, of which 13 were proprietary Chinese medicines (35.14%), 8 (21.62%) were adjuvant therapeutic drugs for liver disease, 4 (10.81%) were antiinfectives and 4 %)Wait. There were 79 cases (47.02%) of ADR involving the skin and their attachments, followed by generalized lesions, 39 cases (23.21%) were reported and 4 cases of severe ADR occurred. Conclusion The monitoring of ADR in patients with liver diseases should be strengthened to ensure the safety and effectiveness of clinical medication.