论文部分内容阅读
目的:探讨Graves病(GD)对骨代谢相关指标及骨密度(BMD)影响。方法:将2013年1月至2015年1月阳江市阳春人民医院收治的72例GD患者作为研究对象,同期健康体检者作为健康对照组(35例),其中GD患者分为GD伴低骨量组(22例)、GD伴OP组(17例)、单纯GD组(33例)。测定BMD、血清游离T3(FT3)、T4(FT4)、促甲状腺素(TSH)、骨钙素(BGP)、Ⅰ型前胶原N端前肽(P1NP)和Ⅰ型胶原羧基端降解产物(β-CTX)等指标。结果:GD患者血清BGP、P1NP、β-CTX、FT3、FT4、高于健康对照组(P<0.05),TSH低于健康对照组(P<0.05)。GD伴低骨量组及GD伴OP组各测量部位BMD值低于健康对照组(P<0.05)。结论:GD可导致高骨转换骨质疏松,治疗时注意BMD及骨代谢指标检测,积极防治疗骨质疏松。
Objective: To investigate the effect of Graves’ disease (GD) on bone metabolism and bone mineral density (BMD). Methods: Seventy-two patients with GD who were admitted to Yangchun People’s Hospital of Yangjiang from January 2013 to January 2015 were enrolled in this study. During the same period, healthy subjects were selected as healthy control group (35 cases). GD patients were divided into GD with low bone mass Group (22 cases), GD with OP group (17 cases), simple GD group (33 cases). The levels of BMD, serum free T3 (FT3), T4 (FT4), thyrotropin (TSH), osteocalcin (BGP), type Ⅰ procollagen N-terminal propeptide (P1NP) -CTX) and other indicators. Results: The levels of serum BGP, P1NP, β-CTX, FT3 and FT4 in GD patients were significantly higher than those in healthy controls (P <0.05), and those in healthy controls were lower than those in healthy controls (P <0.05). The BMD of GD with low bone mass group and GD with OP group was lower than that of healthy control group (P <0.05). Conclusion: GD can lead to osteoporosis with high bone turnover. At the time of treatment, attention should be paid to the detection of BMD and bone metabolism index, and active prevention and treatment of osteoporosis.