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目的:探讨华南汉族成人烟雾病的危险因素。方法:从本院2005年1月-2014年6月收治的烟雾病患者中选取300例为烟雾病组,另选取同期在本院行体检健康人员300例为健康组,对两组观察对象既往病史及实验室检查结果进行回顾性分析,同时对烟雾病相关危险因素进行筛选。结果:两组观察对象既往病史显示,烟雾病组具有糖尿病史、高血压病史、高血脂病史及烟酒史患者明显多于健康组(P<0.05)。两组观察对象实验室检查结果显示,烟雾病组患者血压、血糖、低密度脂蛋白胆固醇明显高于健康组(P<0.05),红细胞及白细胞无明显差异(P>0.05),回归分析结果显示:血压因素、糖尿病因素、血脂异常因素、肥胖因素、嗜酒因素、嗜烟因素、精神因素以及长期缺乏运动因素都是烟雾病的主要危险因素(P<0.05)。结论:华南汉族成人烟雾病的危险因素包括:血压因素、糖尿病因素、血脂异常因素、肥胖因素、嗜酒因素、嗜烟因素、精神因素以及长期缺乏运动因素,临床需进行针对性防治,减少发病率,提高治疗效果。
Objective: To explore the risk factors of adult moyamoya disease in South China. Methods: 300 cases of moyamoya disease were selected from patients with moyamoya disease admitted in our hospital from January 2005 to June 2014. Another 300 healthy people were selected as health group during the same period. Medical history and laboratory test results were retrospectively analyzed, and the risk factors related to moyamoya disease screening. Results: The past medical history of two groups of patients showed that patients with moyamoya disease had history of diabetes mellitus, history of hypertension, history of hyperlipidemia and history of alcohol and tobacco were significantly more than those in healthy group (P <0.05). The results of laboratory tests in the two groups showed that blood pressure, blood glucose and LDL-C in patients with moyamoya disease were significantly higher than those in healthy group (P <0.05), and there was no significant difference between erythrocytes and leukocytes (P> 0.05). The results of regression analysis Blood pressure, diabetes, dyslipidemia, obesity, alcohol abuse, psychosocial factors, and long-term lack of exercise are the major risk factors for moyamoya disease (P <0.05). Conclusion: The risk factors of adult moyamoya disease in South China include: blood pressure, diabetes, dyslipidemia, obesity, alcohol abuse, psychogenic factors and long-term lack of exercise, and clinical need to be targeted to reduce the incidence of morbidity Rate, improve the treatment effect.