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多巴胺(儿茶酚乙胺,DA)是去甲肾上腺素(NE)和肾上腺素(E)生物合成的前体,也是哺乳动物第三种内源性单胺类。本文重点讨论DA在心血管方面的药理作用和临床用途。为了对其全面了解,对其生物转化、中枢神经系统的生理功能等也略加讨论。一、DA与中枢神经系统(C.N.S)的关系 (一)DA在中枢神经系统的分布和生物转化 1.DA在C.N.S的分布:以前认为DA在动物脑内仅是NE生物合成的前体,本身并无生理功能,近年来已有充分实验和临床材料证明:DA不仅是
Dopamine (catecholamine, DA) is a precursor of norepinephrine (NE) and epinephrine (E) biosynthesis and is the third endogenous monoamine in mammals. This article focuses on the cardiovascular pharmacological effects and clinical use of DA. In order to fully understand its biological transformation, the physiological function of the central nervous system is also slightly discussed. I. Relationships between DA and CNS (1) Distribution and Biotransformation of DA in CNS 1. Distribution of DA in CNS: It was previously thought that DA is only a precursor of NE biosynthesis in the animal’s brain, itself There is no physiological function, in recent years have been sufficient experimental and clinical evidence: DA is not only