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β-谷甾醇已如前文所述,近年渐用于临床作为防治动脉粥样硬化症之药物。关于它的含量测定还很少有报导。本文根据它在母核C_(5-6)位上有一个双键进行其溴化定量反应研究,并对具有相同母核结构的甾体激素生产原料和中间体:胆甾醇、去氧表雄酮和妊娠烯醇酮亦同时进行了测定。卤数测定法中采作一氯化碘醋酸溶液的Wijs法和一溴化碘醋酸溶液的Hanus法,二者试剂配置较复杂,已经被认为古典的方法,目前很少被利用。被Генгриновни早在1940年提出的一氯化碘盐酸水溶液,具有很多优点;但是直至1957年以后才较多地发表了其在药物分析中的广泛应用。溴溶于四氯化碳或醋酸中的溶液是一种强的溴化剂,文献记载认
β-Sitosterol has been used as a medicament for prevention and treatment of atherosclerosis in recent years as mentioned above. About its determination of content is still rarely reported. In this paper, we have carried out the bromination quantitative reaction based on its double bond in the C_ (5-6) position of the mother nucleus, and studied the production of steroid hormones and intermediates with the same mother nucleus structure: cholesterol, deoxyglutamine Ketone and gestagenol were also assayed at the same time. Halide determination of iodized acetic acid solution of iodine solution and Wii iodine acetic acid solution Hanus method, the two reagent configuration is more complex, has been considered the classical method, is rarely used. The aqueous solution of iodochloromethane hydrochloride, which was first proposed by Генгриновни in 1940, has many advantages. However, it has not been widely published until 1957 for its extensive use in drug analysis. Bromine dissolved in carbon tetrachloride or acetic acid solution is a strong brominating agent documented in the literature