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目的：探讨妊娠期糖尿病（GDM）患者的甲状腺功能变化情况。方法选取在重庆医科大学附属第一医院确诊的妊娠期糖尿病患者145名（GDM组），健康孕妇120例作为对照（对照组）。分别测定血清促甲状腺素（TSH）、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TpoAb)，糖化血红蛋白（HbA1c）水平。并进行比较分析。结果1.妊娠期糖尿病患者血糖水平与HbA1c有良好的相关性。2.两组间FT4、TSH水平在不同孕期均无明显差异。3.GDM组甲功异常患病率为6.3%，对照组为4.2%。两组间比较差异无统计学意义（P=0.46）。结论尚无明确证据证明妊娠期异常糖代谢会影响甲状腺功能，建议在产检时同时筛查GDM与妊娠甲状腺疾病，便于早期干预，减少不良结局。“,”Objective The aim of this study was to determine the prevalence of abnormal thyroid function during pregnancy in gestational diabetes melitus (GDM) and control group.Methods :There were 145 gestational diabetes melitus women in study group and 120 pregnant women in control group. Serum FT4, TSH,HbA1c and Anti TPO Ab were assessed in each person.Results : Blood glucose in Gestational diabetes melitus have good correlation with HbA1c.There was thyroid dysfunction in 6.3% of GDM and 4.2% of control group.There was no statistically significant difference between thyroid dysfunction in GDM group and control group (P=0.46). Conclusions:Rate of thyroid dysfunction in GDM patients is similar to normal pregnant control women.Thyroid dysfunction is not prevalent in women with GDM.