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目的：探讨采用不同用药方式治疗小儿支原体感染的临床疗效。方法将我院收治的小儿支原体感染患儿56例，随机分为观察组与对照组，各28例，对照组给予阿奇霉素治疗；观察组采用不同剂量，为10mg/kg静脉滴注，对两组患儿的临床疗效、住院时间及各种病症消失时间进行比较。结果观察组患儿治疗总有效率为96.4%，与对照组总有效率89.3%，（P＞0.05）；观察组患儿住院时间及各种疾病消失时间均低于对照组，有统计学意义（P＜0.05）。结论在常规治疗基础上再治疗5d，能有效缩短患儿的住院时间及各种疾病的消失时间，值得在临床上进行推广并应用。“,”Objective: To research on the clinical effect of pediatric mycoplasma infection by using different method of treatment. Method: 56 cases in our hospital were selected and randomly divided into observation group (28 cases)and control group(28 cases), the control group were given to the treatment of azithromycin, observation group were treated as 10mg/kg once day for 5d. Comparing the clinical efficacy, the duration of hospitalization and various symptoms disappear time of two groups. Result: Total effective rate of the observation group were 96.4%, that of the control group were 89.3%, there is no statistical difference (P > 0.05); with the hospitalization time and a variety of diseases disappear time in the observation group were lower than control, (P < 0.05). Conclusion: Treating 5d again after convention method can decreased the hospitalization time and the disappearance time of various diseases, and was worthy of application in clinical.