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目的探讨淋巴细胞免疫治疗原发性及继发性习惯性流产(统称为习惯性流产)及不明原因流产的疗效。方法对习惯性流产及不明原因流产患者,采用丈夫或第三者(男性)健康肘静脉血20ml分离淋巴细胞行主动免疫治疗,并设单纯用静脉丙种球蛋白治疗作对照,观察两组妊娠成功率、婴幼儿随访结果及经济费用情况。结果治疗组妊娠成功43例,成功率为87.8%,平均经济费用为2004±122.3元;对照组妊娠成功31例,成功率为67.4%,平均经济费用为12008±293.4元,两组治疗效果及经济费用差异具有显著性(P<0.01),两组婴幼儿随访结果无显著差异性(P>0.05)。结论淋巴细胞主动免疫疗法可提高患者免疫反应性,有提高妊娠率,降低治疗经济费用,对婴幼儿无影响等优点,不失为治疗习惯性流产的一种简单好方法。
Objective To investigate the efficacy of lymphocyte immunotherapy of primary and secondary habitual abortion (referred to as habitual abortion) and unexplained abortion. Methods In patients with habitual abortion and unexplained abortion, active immunotherapy was performed on 20ml lymphocytes isolated from healthy elbow venous blood of husband or third party (male) and treated with intravenous gamma globulin alone. The pregnancy success was observed Rate, infant follow-up results and economic costs. Results The success rate of pregnancy in treatment group was 43 cases, the success rate was 87.8%, the average cost was 2004 ± 122.3 yuan; control group 31 cases of pregnancy success, the success rate was 67.4%, the average economic cost of 12008 ± 293.4 yuan, The difference in economic cost was significant (P <0.01). There was no significant difference in follow-up between two groups (P> 0.05). Conclusion Active immunotherapy of lymphocytes can improve immunological reactivity, improve pregnancy rate, reduce the cost of treatment, no impact on infants and young children, etc., after all, a simple and easy way to treat habitual abortion.