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本文利用生物检定法通过对儿茶酚胺类递质:去甲肾上腺素(NE),肾上腺素(E),异丙肾上腺素(ISO)和多巴胺(DA)对猪冠状动脉螺旋条作用的观察,得出以上递质均可以不同程度的引起冠脉大支螺旋条舒张,该作用可被β受体拮抗剂普萘洛尔(心得安)所翻转,说明在猪冠脉上,特别是输送支,β2肾上腺素能受体占明显优势,α受体则很少。经典理论认为在冠脉大支上,以α受体占优,NE可致冠脉收缩,甚至痉挛,本结果与此有明显不同,提示人们是否需要对冠脉上肾上腺素能受体的分布及儿茶酚胺类递质的作用重新认识。
In this paper, we observed the effects of catecholamine neurotransmitters NE, epinephrine, isoproterenol (ISO) and dopamine (DA) on porcine coronary arteries by bioassay. The above neurotransmitters all can cause coronary artery spiral dilatation in varying degrees, which can be overturned by propranolol (propranolol), which shows that in porcine coronary arteries, especially the branch of artery, β2 Adrenergic receptors accounted for obvious advantages, alpha receptors are few. Classical theory that in the coronary artery, the α receptor dominant, NE can cause coronary systole, or even spasm, and the results are significantly different, suggesting that people need on the coronary adrenergic receptor distribution And the role of catecholaminergic neurotransmitters re-understanding.