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利用全血细胞培养技术，进行脂多糖（ＬＰＳ）对中性粒细胞弹性蛋白酶（ｅｌａｓｔａｓｅ）释放影响的研究，发现ＬＰＳ是一个强有力的弹件蛋白酶释放刺激物。这个作用是剂量依赖性的，是通过肿瘤坏死因子－α（ＴＮＦ－α）实现的。提示ＴＮＦ－α在ＬＰＳ引起的炎症反应中发挥着重要作用。
The use of whole blood cell culture to study the effect of lipopolysaccharide (LPS) on the release of elastase from neutrophils revealed that LPS is a potent prolamin release stimulator. This effect is dose-dependent and is achieved by tumor necrosis factor-alpha (TNF-alpha). It is suggested that TNF-α plays an important role in the inflammation caused by LPS.