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正常上皮细胞的生长与分化需要维生素A。维生素A缺乏将导致消化道、呼吸道和眼球表面杯状细胞数量减少和上皮细胞角化。重者可致眼干燥和角膜软化症。维生素A缺乏症已成为发展中国家儿童致盲的首要原因。直到近年此病唯一有效的治疗仍系全身给予维生素A。本文通过动物实验证实了全身给予维生素A治疗的同时局部点用维生素A_1或维生素A_1酸能更快地减轻角膜干燥症的角化并使之迅速透明。本文动物实验选用新西兰白兔(体重在半公斤以下),饲以缺乏维生素A之酪蛋白而造成实验性干眼病,3—4个月后每周行裂隙灯眼部检查,并将角膜病变进行分期,然后将它们分成四组、分别给予一眼点用0.1％或0.2％的维生素
Vitamin A is required for the growth and differentiation of normal epithelial cells. Vitamin A deficiency results in a decrease in the number of goblet cells and epithelial keratosis in the digestive tract, respiratory tract and eyeball. In severe cases can cause eye dryness and corneal softening disease. Vitamin A deficiency has become the leading cause of childhood blindness in developing countries. Until the only effective treatment of the disease in recent years is still systemic administration of vitamin A. In this paper, animal experiments confirmed that the systemic administration of vitamin A while local vitamin A or vitamin A acid can be more quickly reduce the corneal keratosis and make it transparent quickly. New Zealand white rabbits (weighing less than half a kilogram) were selected for the animal experiment. Experimental dry eye was induced by casein lacking vitamin A. After 3-4 months, eye examination of slit lamp was performed weekly and corneal lesions were performed Staging, and then they are divided into four groups, were given a spot with 0.1% or 0.2% vitamins