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目的 比较静脉应用普罗帕酮与毛花苷丙治疗快速心房颤动 (简称房颤 )并发充血性心力衰竭 (心衰 )患者心室率的即时效应及安全性。方法 4 6例房颤患者 ,心室率≥ 12 0次 /min ,心功能Ⅱ级以上 (NYHA)。采用随机方法分组 ,分别静脉应用普罗帕酮与毛花苷丙。结果 普罗帕酮、毛花苷丙组控制房颤快速心室率的总有效率分别为81.0 %和 6 0 .9% (P <0 .0 5 ) ;心室率平均下降幅度分别为 35 %和 2 5 % (P <0 .0 1) ;平均起效时间分别为 (2 3.1±8.2 )min和 (5 0 .7± 10 .4 )min(P <0 .0 1)。普罗帕酮有 1例出现症状性低血压 ,1例出现第一度房室传导阻滞 ,无心衰加重表现。结论 静脉应用普罗帕酮能迅速、安全、有效地控制房颤并发充血性心衰患者的快速心室率
Objective To compare the immediate effect and safety of intravenous propafenone and curculigoside in the treatment of ventricular rate in patients with rapid atrial fibrillation (AF) complicated with congestive heart failure (CHF). Methods In 46 patients with atrial fibrillation, the ventricular rate was ≥12 0 beats / min and the cardiac function was grade Ⅱ or higher (NYHA). Randomized grouping was given intravenous propafenone and curcumin C respectively. Results The total effective rates of propafenone and curculigin in the control of rapid ventricular rate of atrial fibrillation were 81.0% and 60.9%, respectively (P <0.05), and the average decreases of ventricular rate were 35% and 2% The mean effective time was (2 3.1 ± 8.2) min and (50.7 ± 10.4) min (P <0.01), respectively. One case of propafenone developed symptomatic hypotension, and one case had the first AV block without worsening of heart failure. Conclusion Intravenous propafenone can rapidly, safely and effectively control the rapid ventricular rate in patients with atrial fibrillation complicated by congestive heart failure