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Objective To optimize the preparation of the Naoxueling capsules.Methods To optimize the extraction of the Naoxueling prescription successively with alcohol and water,several principal ingredients in the final extracts were evaluated and data were analyzed by the orthogonal test.The capsule-molding process was investigated by measuring the angle of repose and the moisture absorption percentage.Results The optimum process of the alcohol extraction was the refluxing of herbs first in twelve-fold volume of 75% ethanol for 2 h,then in eight-fold volume of 75% ethanol for 1.5 h,and finally in seven-fold volume of 75% ethanol for 0.5 h.Meanwhile,the best water extraction was performed by boiling samples in twelve-fold amount of water for 2 h followed by another 1 h in eight-fold amount of water.To mold the capsule,the appropriate ratio of micro-powder to dextrin was 20:1.Conclusion The preparation technology of the Naoxueling capsules is reasonable and feasible,which provides evidences for the industrial manufacture.
Objective To optimize the preparation of the Naoxueling capsules. Methods To optimize the extraction of the Naoxueling prescription successively with alcohol and water, several principal ingredients in the final extracts were evaluated and evaluated by the orthogonal test. The capsule-molding process was investigated by measuring the angle of repose and the moisture absorption percentage. Results of the optimum process of the alcohol extraction was the refluxing of herbs first in twelve-fold volume of 75% ethanol for 2 h, then in eight-fold volume of 75% ethanol for 1.5 h, and finally in seven-fold volume of 75% ethanol for 0.5 h.Meanwhile, the best water extraction was performed by boiling samples in twelve-fold amount of water for 2 h followed by another 1 h in eight-fold amount of water.To mold the capsule, the appropriate ratio of micro-powder to dextrin was 20: 1.Conclusion The preparation technology of the Naoxueling capsules is reasonable and feasible, which provides evidences for t he industrial manufacture.