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通过测定特异性抗体、淋巴细胞转化和巨噬细胞（ＭΦ）吞噬率，观察卡介菌多糖核酸（ＢＣＧ－ＰＳＮ）和死卡介菌（死卡）对抗环磷酰胺（ＣＴＸ）免疫抑制的作用。结果显示：ＢＣＧ－ＰＳＮ和死卡能增加小鼠有核脾细胞和腹腔细胞数、促进Ｔ淋巴细胞转化、促进血凝抑制抗体产生和增强ＭΦ的吞噬功能。ＣＴＸ对上述免疫细胞均有不同程度的抑制作用，尤对Ｂ细胞产生抗体的抑制作用最强。ＢＣＧ－ＰＳＮ和死卡对ＣＴＸ的免疫抑制有不同程度的保护作用，尤对ＭΦ吞噬功能保护力最强。结果提示，ＢＣＧ－ＰＳＮ可望用于临床使用ＣＴＸ的病人以增强免疫力。
The effect of BCG-PSN and dead card on CTX immunosuppression was observed by measuring the rate of phagocytosis of specific antibodies, lymphocytes and macrophages (MΦ) . The results showed that: BCG-PSN and dead card can increase the numbers of nucleated spleen cells and peritoneal cells, promote the transformation of T lymphocytes, promote the inhibition of antibody production by hemagglutination and enhance the phagocytosis of MΦ. CTX on the above-mentioned immune cells have different degrees of inhibition, especially on the B-cell antibody produced the strongest inhibition. BCG-PSN and dead card on CTX immunosuppression have different degrees of protection, especially for the protection of MΦ phagocytosis strongest. The results suggest that BCG-PSN is expected to be used clinically in patients with CTX to enhance immunity.