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目的探讨早期乳酸清除率对机械通气治疗慢性阻塞性肺疾病加重期(AECOPD)合并呼吸衰竭患者预后的影响。方法选取AECOPD合并呼吸衰竭住院患者48例进行观察研究,根据患者病情转归分为存活组32例和死亡组16例;测定患者治疗前与治疗6 h后的动脉血乳酸、动脉血气、APACHEⅡ评分及早期(6 h)乳酸清除率。结果存活组中高乳酸清除率为84.4%,高于死亡组的18.8%,差异有统计学意义(P<0.01)。结论早期乳酸清除率有助于AECOPD合并呼吸衰竭的预后判断和治疗指导。
Objective To investigate the effect of early lactic acid clearance on the prognosis of patients with chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure during mechanical ventilation. Methods Forty-eight patients with AECOPD and respiratory failure were enrolled in this study. According to the patient’s condition, they were divided into survival group (32 cases) and death group (16 cases). The arterial blood lactate, arterial blood gas and APACHEⅡ score And early (6 h) lactic acid clearance. Results In the survival group, the clearance rate of high lactic acid was 84.4%, which was higher than that of the death group (18.8%), the difference was statistically significant (P <0.01). Conclusion Early lactic acid clearance contributes to prognosis and treatment of AECOPD complicated with respiratory failure.