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[目的]探讨肝硬化血清-腹水清蛋白梯度(SAAG)和肿瘤抗原125(CA125)水平与肝损害和腹水蓄量的关系。[方法]肝硬化腹水患者87例,根据Child-Pugh改良计分法判定肝功能损害程度,A级22例,B级38例、C级27例,检测SAAG及腹水CA125水平,分别计算3组的SAAG及CA125均值,结合SAAG和CA125水平,观察腹水再发生的情况。[结果]SAAG和CA125随Child-Pugh肝功能评分的增加均逐渐增高,各组之间比较差异有统计学意义(P≤0.01),且随着腹水量的增多,SAAG和CA125水平也呈逐渐升高趋势。SAAG和CA125呈正相关,随肝功能的减退逐渐升高。[结论]SAAG和CA125水平可作为反映肝硬化患者肝损害程度的指标之一,并对衡量肝硬化患者的预后,监测肝硬化患者腹水消长有一定的参考价值。
[Objective] To investigate the relationship between serum hepatic cirrhosis serum ascites albumin gradient (SAAG) and tumor antigen 125 (CA125) levels and hepatic impairment and ascites volume. [Methods] 87 patients with cirrhosis and ascites were divided into two groups according to Child-Pugh’s modified score method: 22 cases in grade A, 38 cases in grade B and 27 cases in grade C, SAAG and CA125 in ascites were detected, Of SAAG and CA125 mean, combined with SAAG and CA125 levels observed ascites recurrence. [Results] Both SAAG and CA125 increased gradually with the increase of Child-Pugh’s liver function score (P≤0.01), and the levels of SAAG and CA125 gradually increased with the increase of ascites Increase trend. SAAG and CA125 was positively correlated, with the decline of liver function gradually increased. [Conclusions] The levels of SAAG and CA125 can be used as an index to reflect the degree of liver damage in cirrhotic patients. It is also useful for measuring the prognosis of patients with cirrhosis and monitoring the growth of ascites in patients with cirrhosis.